We have 4K screen on our user's Windows 10 laptops and their Windows' dpi scaling is usually set anywhere between 150% and 250% because of the ultra-high native resolution of the screens. Their problem with LIfeSize presents itself when they try to hook up to a projector, mirror their screen to the projector and share their screen on LifeSize. To present to a crowd, they plug their laptops into a lower resolution projector (usually 1366x768) and mirror their screens to the projector. Everything works OK with this setup and nothing seems to be off until they start LifeSize and try to share their screen (desktop). Once they do that, LifeSize's black sharing bar lands right in the middle of their screen and can't be moved.
The only way to get the bar to move (i.e.jump to the top or bottom of the screen) where it's supposed to be is to right-click the Windows Desktop > Display Settings > Display > Scale and Layout > Change the size of text, apps and other items and change the dpi scaling. LifeSize's sharing bar will then jump from the middle of the screen to the top or bottom of the screen as it should. It's really annoying; almost like LifeSize is getting confused with the combination of disparate resolution between the laptop and projector and Windows' dpi scaling.